Engine misfire on a 2021 Ford E-350 cutaway, 7.3L V8, used for parcel delivery. The vehicle was delivered to Ford of Spartanburg (Ford dealership) for diagnosis. The vehicle is still out of service. Ford's diagnosis, Repair Order 593079, June 26, 2026: "WILL NEED TO REPLACE ALL SPARK PLUGS AND WIRES, WILL ALSO NEED TO REPLACED ALL COILS DUE TO MISFIRES ON ALMOST EVERY CYLINDER." The Ford service advisor wrote the same day: "The engine also has a misfire that is unrelated to the transmission concern." Ford quoted $4,376.35 for the ignition components and wrote: "AFTER REPAIRING TRANSMISSION WILL NEED TO DIAGNOSE ALL OTHER CONCERNS WITH VEHICLE, CANNOT DIAG ANYTHING AT MOMENT DUE TO NOT BEING ABLE TO DRIVE VEHICLE." Ford has not completed the engine diagnosis; on July 27, 2026 it advised against a compression test and offered one at $920.00. This is the second engine failure on this VIN. In January 2024 at 103,177 miles, the same Ford dealership diagnosed "Found a misfire and low compression on cylinder 3, ordered engine and replaced the engine with new intake gaskets, exhaust manifold gaskets, torque converter nuts, found the reinforcement cracked and replaced it" and installed a Ford service engine, part LC3Z-6006-B (Invoice 551352C; I paid $10,000.00). That Ford replacement engine is the one now misfiring, after at least 63,580 miles. Note on mileage: Ford's RO 593079 records 103,778 miles; Ford's own January 2024 invoice recorded 103,177 and independent records show 166,757 on January 12, 2026 and 169,140 on February 4, 2026. The Ford RO figure is not an actual reading. The same 7.3L engine has failed on nine vehicles in this fleet; the federal safety agency holds VOQ 11582566, 11582592, 11582598, 11582601, 11582604 and ODI 11714692, 11714694, and the federal safety agency ODI (Mr. J. Williams) has the complete record as of September 6, 2026. North Carolina DOJ Consumer Protection File No. 2026-180591 is open on the same matter.
2021 Ford E-350 engine problems
11 complaints (50% of all complaints for this car).
- owner complaints
- 11
- of this car's complaints
- 50%
- crashes
- 0
- recalls
- 2
Which part fails
Owners did not name a specific part.
At what mileage
Complaints by mileage at the time of the problem.
Ford E-350 engine problems in other years
Specific symptoms reported on the 2021 Ford E-350 engine
Phrases found in the owners' own descriptions, so one complaint can mention several symptoms.
Related recalls
Engine
- What is wrong
- Ford Motor Company (Ford) is recalling certain 2021 E-350 and E-450 vehicles that received an incomplete software update under recall 20V795. The engine cover may become excessively hot.
- Risk
- Direct contact with certain areas of engine cover surface in the passenger compartment may increase the risk of injury or burns to the skin of the driver or front seat passenger.
- Remedy
- Dealers will update the powertrain calibration for heat management under elevated idle conditions, free of charge. Owner notification letters were mailed January 7, 2026. Owners may contact Ford customer service at 1‑866‑436‑7332. Ford's number for this recall is 25SC7. Vehicle Identification Numbers (VINs) involved in this recall will be searchable on beginning December 22, 2025.
Recall number 25V793000 · Recall details
Engine
- What is wrong
- Ford Motor Company (Ford) is recalling certain 2021 E-350 and E-450 vehicles. The underside of the engine cover may have mispositioned insulation, allowing the cover to get excessively hot.
- Risk
- Direct and continuous contact with certain areas of engine cover surface in the passenger compartment may increase the risk of injury or burns to the skin of the driver or front seat passenger.
- Remedy
- Ford will notify owners, and dealers will inspect the engine cover for gaps between the rubber seal and the insulation. If gaps are present, the dealer will install engine cover insulation patches in the right hand and left hand inner lower corners of the engine cover. The dealer will also update the powertrain calibration for heat management under elevated idle conditions should a vehicle be equipped with SEIC or BCP, free of charge. The recall began February 15, 2021. Owners may contact Ford customer service at 1‑866‑436‑7332. Ford's number for this recall is 20S73.
Recall number 20V795000 · Recall details
Related investigations
Camshaft and Lifter Failure in Ford 7.3L Gasoline Engines
The Office of Defects Investigation (ODI) received a petition on June 13, 2026, requesting an investigation into camshaft and lifter failures in Ford 7.3L gasoline engines used in 2021-2022 Ford E-350 and 2021 Ford F59 and F-750 vehicles. The Petitioner alleges that insufficient oil lubrication at low idle (~6 psi) causes severe wear on lifter rollers and camshaft lobes, leading to catastrophic engine failure and sudden loss of motive power while driving at highway speeds with little to no warning. The petition further alleges that Ford Motor Company was aware of the root cause and released a software calibration patch raising idle speed to ~1,000 RPM, but failed to initiate a public safety recall or notify vehicle owners. The petition itself can be reviewed at under ODI number 11764421. This defect petition has been opened to evaluate the issue and determine whether to grant or deny the petition.
DP26011
What 2021 Ford E-350 owners say
Most recent owner complaints, unedited.
Engine failure on a 2021 Ford E-350 cutaway, 7.3L V8, used for parcel delivery. The vehicle was taken out of service and has not run since. Two diagnoses, both in writing. ACME Mobile Service, July 27, 2026, at 152,760 miles: "Found the #5 cylinder is completely disabled and dropped out. Truck will need a new motor." Ford of Spartanburg (Ford dealership), Repair Order 595835, August 25, 2026: "FOUND ENGINE IS KNOCKING, WILL NEED TO REPLACE MOTOR." Ford quoted $16,000.82 for a long-block replacement. The engine is available for inspection. This is the second engine failure on this VIN. In March 2023 at 83,575 miles the engine was rebuilt with new Ford parts (camshaft, sixteen lifters, rocker arms, cylinder heads) after a camshaft and lifter failure. On the day the rebuild was completed the shop recorded "03/31/2023- NEW ENGINE FAILED. ENGINE STARTED KNOCKING AND HAD NOISE COMING FROM TOP END." and Ford replaced the complete engine under warranty in April 2023 (Ford claim CAS-42271539-G0F3ZF). That Ford replacement engine is the one that has now failed, after 69,185 miles. Ford's own repair order of August 25, 2026 lists Safety Recalls 20S73 and 24S07 for this VIN at $0.00, i.e. not performed, while the vehicle sat at the Ford dealership. Ford Customer Experience declined assistance on August 25, August 28 and September 9, 2026 and closed the case. The same 7.3L engine has failed on nine vehicles in this fleet; the federal safety agency already holds VOQ 11582566, 11582592, 11582598, 11582601, 11582604 and ODI 11714692, 11714694 on those, and the federal safety agency ODI (Mr. J. Williams) has the complete vehicle-by-vehicle record as of September 6, 2026. North Carolina DOJ Consumer Protection File No. 2026-180591 is open on the same matter.
fatal Camshaft and lifter failure requiring an engine replacement
Engine failure at 78,172, excess wear to the camshaft lobes and valve tappet surface. We have had 22 failures. There was a recall -24B27 for 2021 and 2022 models year for idle oil pressure. Most vans had 70 to 80k on them by the time we received a letter. Some engine have been changed twice. Ford has a serious problem and is not acknowledging it. Please help! Montachusett Regional Transit Authority , Fitchburg MA 01420
This is one of 4 of my 2021 ford econoline fleet vehicles purchased in 2021 that have had engine failure. I am one of many contractors in my area and others around the country who have had this issue with the same F59 engine. Ford has failed to issue a recall.
This is one of 4 of my 2021 ford econoline fleet vehicles purchased in 2021 that have had engine failure. I am one of many contractors in my area and others around the country who have had this issue with the same F59 engine. Ford has failed to issue a recall.
This is one of 4 of my 2021 ford econoline fleet vehicles purchased in 2021 that have had engine failure. I am one of many contractors in my area and others around the country who have had this issue with the same F59 engine. Ford has failed to issue a recall.
See attached document for complaint,
See attached document for complaint,
See attached document for complaint,
Questions about the 2021 Ford E-350 engine
Does the 2021 Ford E-350 have engine problems?
Owners have filed 11 complaints about the engine of the 2021 Ford E-350, 50% of all its complaints, more than any other problem.
At what mileage do 2021 Ford E-350 engine problems start?
Not enough complaints include the mileage to tell.
Was there a recall on the 2021 Ford E-350 engine?
Yes, 2 recalls: 25V793000, 20V795000. Check your VIN to see if your car still needs the free repair.
What year does the Ford E-350 have bad engine?
The Ford E-350 model years with the most engine complaints are 2005 (21 complaints), 2002 (20 complaints) and 2001 (17 complaints).
Other 2021 Ford E-350 problems
Brakes 7Steering 7Driver assistance 1Fuel system 1
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